Science of Aging
Understanding the biology of longevity
Aging is not a mystery. Scientists have identified its molecular drivers — and many of them are now targetable. Here is what we know, and how we act on it.
The Hallmarks of Aging
First described in a landmark 2013 paper in Cell, the hallmarks of aging are the molecular and cellular processes that underlie the progressive deterioration we call aging. Our protocols are designed to address each one.
Genomic Instability
DNA damage accumulates over time. Our protocols include compounds that enhance DNA repair mechanisms and reduce the mutational burden that drives cellular dysfunction.
Our Interventions
—NAD+ therapy
—Antioxidant protocols
—Senolytic agents
Telomere Attrition
Telomeres shorten with every cell division. When they become critically short, cells enter senescence or die. We use evidence-based interventions shown to slow and, in some cases, reverse telomere shortening.
Our Interventions
—Hyperbaric oxygen therapy
—Lifestyle optimization
—Telomerase-supporting compounds
Epigenetic Alterations
The epigenome — the system of chemical marks that control gene expression — drifts dramatically with age. Epigenetic age is now measurable and is one of the strongest predictors of mortality and disease risk.
Our Interventions
—NAD+ / sirtuins
—Dietary interventions
—Reprogramming research protocols
Loss of Proteostasis
The cell's ability to maintain proper protein folding and degradation declines with age, leading to accumulation of damaged proteins. Autophagy enhancement is a key target.
Our Interventions
—Fasting protocols
—Rapamycin (selected cases)
—Spermidine
Cellular Senescence
Senescent cells accumulate with age and release a toxic cocktail of inflammatory signals (the SASP) that damages surrounding tissue. Clearing them with senolytic agents is one of the most exciting areas of longevity medicine.
Our Interventions
—Dasatinib + Quercetin
—Fisetin
—Navitoclax protocols
Mitochondrial Dysfunction
Mitochondria — the cell's energy factories — decline in number and function with age. Restoring mitochondrial health is central to every longevity protocol we design.
Our Interventions
—NAD+ / NMN
—PQQ and CoQ10
—Mitochondrial peptides
Chronic Inflammation
Low-grade, chronic inflammation — called inflammaging — underlies virtually every age-related disease. Reducing it through targeted interventions is a cornerstone of our approach.
Our Interventions
—IV anti-inflammatory therapy
—Dietary frameworks
—Stem cell immunomodulation
Apply the science to your biology
Take our longevity assessment to identify which hallmarks of aging are most active in your biology.